Leukocyte Adhesion Molecules by Alan S. Rosenthal (auth.), Timothy A. Springer Ph.D., Donald

By Alan S. Rosenthal (auth.), Timothy A. Springer Ph.D., Donald C. Anderson M.D., Robert Rothlein Ph.D., Alan S. Rosenthal (eds.)

Leukocyte adhesion molecules promise to be powerful as antigens within the antibody-directed leucocyte removing therapy ahead of grafting or in instances of acute and protracted inflammatory disorder. This complete evaluation of up to date examine offers thorough discussions of the constitution of those molecules, their in vitro function, and the function that they play in vivo as evidenced through effects proven in inflammatory types the place antibodies opposed to those molecules are given to inhibit their functionality. The combination of simple technology and medical functions offers transparent proof of the organic relevance of cell-cell interactions and the numerous capability medical dividends afforded through knowing the molecular foundation of cellphone adhesion.

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Leukocyte Integrins 17 localized to band 2lq22 by in situ hybridization to metaphase chromosomes (73). 3) by hybridization to a panel of chromosome 21 deletion mutants and linkage of restriction fragment length polymorph isms (74). The {j subunit gene may be a useful marker for analysis of trisomy 21 in Down's syndrome. In addition, band 21q22 has been identified as a breakpoint in chromosomal translocations (t(3;21)(q25;q22) associated with the blast phase of chronic myelogenous leukemia (CML) (75).

J ImmunoI140:693-699, 1988. 93. Butcher EC: The regulation of lymphocyte traffic. Curr Topics Microbiol ImmunoI128:85-122, 1986. 94. Patarroyo M, Beatty PG, Fabre JW, Gahmberg CG: Identification of a cell surface protein complex mediating phorbol ester-induced adhesion (binding) among human mononuclear leukocytes. Scand J Immunol22: 171-182, 1985. 95. Mentzer SJ, Gromkowski SH, Krensky AM, Burakoff SJ, Martz E: LFA-I membrane molecule in the regulation of homotypic adhesions of human B lymphocytes.

Miller D, Springer T A. Biosynthesis and glycosylation of p 150,95 and related leukocyte adhesion proteins. J ImmunoI139:842-847, 1987. 37. Sastre L, Kishimoto TK, Gee C, Roberts T, Springer T A: The mouse leukocyte adhesion proteins Mac-l and LFA-I: Studies on mRNA translation and protein glycosylation with emphasis on Mac-I. J ImmunoI137:10601065, 1986. 38. Dahms NM, Hart GW: Lymphocyte function-associated antigen I (LFA-l) contains sulfated N-linked oligosaccharides. J Immunol 134:3978-3986, 1985.

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