Oncogenes and Growth Control by Patricia Kahn, Thomas Graf

By Patricia Kahn, Thomas Graf

How is progress managed in basic cells? How are the expansion keep watch over mechanisms perturbed in melanoma cells? This booklet presents an updated description of study aimed toward resolving those questions. it's equipped into 4 sections, each one containing a sequence of brief stories written by way of specialists within the box. the final headings are: progress elements, receptors, and comparable oncogenes: transduction of mitogenic indications and ras oncogenes; nuclear oncogenes and legislation of gene expression; and a number of steps excited about malignant transformation. The articles emphasize ideas instead of unique proof and are meant not just for experts within the box but additionally for readers, equivalent to physicians and complex scholars, who desire to remain abreast of advancements in a single of the main intriguing fields in present biomedical research.

Show description

Read or Download Oncogenes and Growth Control PDF

Best nonfiction_8 books

Advances in Object-Oriented Graphics I

Object-oriented structures have received loads of acceptance lately and their software to pictures has been very profitable. This publication files a few fresh advances and shows a variety of components of present examine. the aim of the ebook is: - to illustrate the extreme functional software of object-oriented tools in special effects (including person interfaces, picture synthesis, CAD), - to envision striking learn concerns within the box of object-oriented photographs, and particularly to investi- gate extensions and shortcomings of the technique whilst utilized to special effects.

Organizational Change and Information Systems: Working and Living Together in New Ways

This booklet examines quite a number matters rising from the interplay of data applied sciences and organizational structures. It encompasses a choice of examine papers targeting issues of becoming curiosity within the box of data platforms, association reviews, and administration. The booklet bargains a multidisciplinary view on info structures aiming to disseminate educational wisdom.

Additional resources for Oncogenes and Growth Control

Sample text

It was therefore surprising to discover that pp60c-src is expressed in certain differentiated cells which had ceased dividing. Furthermore, although species from sponges to man express the c-src gene in a variety of tissues (Collett et al. 1978; Oppermann et al. 1979; Rohrschneider et al. 1979; Schartl and Barnekow 1982; Lev et al. 1984), the highest levels are found in brain and related neural tissues that do not proliferate (Barnekow et al. 1982). In embryonic tissues one might expect that pp60c-src protein would be expressed in the most actively dividing and differentiating cell masses.

Cancer Cells 3 :425 - 432 Maness PF, Sorge LK, Fults DW (1986) An early developmental phase of pp60c-src expression in the neural ectoderm. Dev Bioi (in press) Oppermann H, Levinson A, Varmus H, Levintow L, Bishop JM (1979) Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proc Nat! Acad Sci USA 76:1804-1808 Tissue-Specific Expression and Possible Functions of pp60 c-src 31 Parsons SJ, Creutz CE (1986) p60c-src activity detected in the chromaffin granule membrane_ BBRC (in press) Ralston R, Bishop JM (1985) The product of the proto-oncogene c-src is modified during the cellular response to platelet-derived growth factor.

Dev Bioi 104:9-17 Livett BG (1984) Adrenal medullary chromaffin cells in vitro. Physiol Rev 64:1103 -1161 Maness PF, Fults DW (1985) Immunocytochemical mapping of pp60 c-src in the developing nervous system. Cancer Cells 3 :425 - 432 Maness PF, Sorge LK, Fults DW (1986) An early developmental phase of pp60c-src expression in the neural ectoderm. Dev Bioi (in press) Oppermann H, Levinson A, Varmus H, Levintow L, Bishop JM (1979) Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src).

Download PDF sample

Rated 4.49 of 5 – based on 19 votes