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Additional resources for Oncogenes and Growth Control
It was therefore surprising to discover that pp60c-src is expressed in certain differentiated cells which had ceased dividing. Furthermore, although species from sponges to man express the c-src gene in a variety of tissues (Collett et al. 1978; Oppermann et al. 1979; Rohrschneider et al. 1979; Schartl and Barnekow 1982; Lev et al. 1984), the highest levels are found in brain and related neural tissues that do not proliferate (Barnekow et al. 1982). In embryonic tissues one might expect that pp60c-src protein would be expressed in the most actively dividing and differentiating cell masses.
Cancer Cells 3 :425 - 432 Maness PF, Sorge LK, Fults DW (1986) An early developmental phase of pp60c-src expression in the neural ectoderm. Dev Bioi (in press) Oppermann H, Levinson A, Varmus H, Levintow L, Bishop JM (1979) Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proc Nat! Acad Sci USA 76:1804-1808 Tissue-Specific Expression and Possible Functions of pp60 c-src 31 Parsons SJ, Creutz CE (1986) p60c-src activity detected in the chromaffin granule membrane_ BBRC (in press) Ralston R, Bishop JM (1985) The product of the proto-oncogene c-src is modified during the cellular response to platelet-derived growth factor.
Dev Bioi 104:9-17 Livett BG (1984) Adrenal medullary chromaffin cells in vitro. Physiol Rev 64:1103 -1161 Maness PF, Fults DW (1985) Immunocytochemical mapping of pp60 c-src in the developing nervous system. Cancer Cells 3 :425 - 432 Maness PF, Sorge LK, Fults DW (1986) An early developmental phase of pp60c-src expression in the neural ectoderm. Dev Bioi (in press) Oppermann H, Levinson A, Varmus H, Levintow L, Bishop JM (1979) Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src).