By Robert B. Raffa, Scott M. Rawls, Elena Portyansky Beyzarov
This up-to-date variation of Netter's Illustrated Pharmacology enables you to take a different visible method of realizing either the fundamental technology and medical purposes of pharmacology. Designed to be appropriate and utilized in conjunction with different pharmacology assets, this clinical reference e-book bargains a shiny, uniquely potent visible presentation of the pharmacodynamic dating among medicines and the human physique. And with the hot addition of pupil seek advice on-line entry, Netter's Illustrated Pharmacology is much more handy than ever before!
* on hand on-line for the 1st time! seek the whole contents of Netter's Illustrated Pharmacology it doesn't matter what your position with handy entry to pupil Consult.
* Visually seize an important rules in pharmacology with succinct, easy-to-understand displays of introductory pharmacologic rules in accordance with vintage pictures by means of Frank Netter, in addition to dynamic new illustrations from different gifted scientific artists.
* learn the way medications are used to regard particular issues within the physique, in addition to their results on a specific web site, with a layout divided via organ method and full-color illustrations of the structures themselves.
* entry in-depth information at the must-know components of every pharmacologic precept with transparent, concise notes situated underneath the corresponding image.
"This is the final word publication for the visible learner. Even if you at the beginning examine most sensible from basic succinct outlines of excessive yield proof, will locate this booklet to be the simplest for the ultimate integration of simple sciences into the artwork of sufferer care sooner than board examinations or scientific reports. i might suggest this e-book for each medical professional who has a few desire for figuring out how medicinal drugs work."
-Doody's publication evaluate Service
"This up to date model of Netter's Illustrated Pharmacology contains new illustrations that accompany Netter's originial drawings. the excellent annotated illustrations and succinct accompanying textual content, by no means fail to elicit an 'Ah, Now I understand!" response. through illuminating the most recent advancements in molecular biology, mobile body structure and neurophysiology, pharmacodynamics/ kinetics, and intricate study findings, it is going to improve the reader's easy knowing of pharmacology... As a textbook for healthcare clinicans, undergraduate scholars, or as an illuminating discourse for the overall reader it's extraordinary. The sufferer/ doctor interactions are proven to be a very means approach, and the axiomatic caricatures of affliction presentation may be instantly recognisable. One wish to imagine that the ebook will elicitan empathy for either events that may stick with the practitioner forever."
-GlycosMedia, March 2014
via Robert B. Raffa, PhD, Temple college college of Pharmacy Philadelphia, Pennsylvania; Scott M. Rawls, PhD, Temple college university of Pharmacy Philadelphia, Pennsylvania and Elena Portyansky Beyzarov, PharmD, Director of medical Affairs Pharmacy occasions Plainsboro, NJ
Read or Download Netter's Illustrated Pharmacology (Updated Edition) PDF
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Extra info for Netter's Illustrated Pharmacology (Updated Edition)
Binding pocket ... while the other enantiomer is only a partial match. Figure 1-10 Stereochemistry and 3-Dimensional Fit One enantiomer of a racemic pair is often observed to bind more avidly to (has greater affinity for) a receptor than does the other enantiomer of the pair. Because the only difference between them is the stereochemistry, the 3-dimensional shape of a molecule must be a crucial characteristic for binding affinity. The relation between chemical structure and biologic response is 12 known as the SAR and is a common focus of drug discovery efforts.
EFFECT EFFECT EFFECT Addition of antagonist blocks ligand-receptor interactions, reducing the cumulative effect. EFFECT Figure 1-9 Antagonists Some molecules have physiochemical and stereochemical traits that impart affinity for a receptor but cannot activate it. Such molecules bind to (occupy) receptors and block access of agonists, thereby reducing the effects of agonists. Such pharmacologic antagonists do not elicit biologic effects directly; they modify the physiologic process that is maintained by agonist action (eg, by neurotransmitters).
Examples of drugs that are receptor antagonists are atropine (muscarinic cholinergic), d-tubocurarine (nicotinic cholinergic), atenolol (adrenoceptor), spironolactone (mineralocorticoid), diphenhydramine (histamine H1), ondansetron (5-HT), flumazenil (benzodiazepine), haloperidol (dopamine), and naloxone (opioid). Chemical antagonism (eg, neutralization of gastric acid by chemical bases) or physiologic antagonism, in which an effect of one drug opposes an effect of another agent (eg, epinephrine used to counteract the histamine response to a bee sting), of drug effects can also occur.