Molecular and Subcellular Cardiology: Effects of Structure by Harry A. Fozzard, Gregory Lipkind (auth.), Professor Samuel

By Harry A. Fozzard, Gregory Lipkind (auth.), Professor Samuel Sideman, Professor Rafael Beyar (eds.)

The Henry Goldberg Workshops have been organize to deal with the subsequent objectives: (1) To foster interdisciplinary interplay among scientists and cardiologists, determine lacking hyperlinks, and catalyze new rules. (2) to narrate easy microscale phenomena to the worldwide, clinically manifested cardiac functionality. (3) to narrate conceptual modeling and quantitative research to experimental and medical information. (4) To inspire overseas cooperation in an effort to disperse clinical and technological knowhow and bring about larger figuring out of the cardiac method. the 1st Henry Goldberg Workshop, held in Haifa in 1984, brought the concept that of interplay among cardiac mechanics, electric activation, perfusion, and metabolism, emphasizing imaging within the scientific atmosphere. the second one Workshop, in 1985, mentioned an analogous parameters with a slant in the direction of the keep an eye on points. The 3rd Goldberg Workshop, held within the united states at Rutgers college in 1986, highlighted the transformation of the microscale activation phenomena to macroscale task and function, pertaining to electrophysiology, strength metabolism, and cardiac mechanics. The fourth Goldberg Workshop, in 1987, endured the trouble to clarify the interactions one of the numerous parameters affecting cardiac functionality, with emphasis at the ischemic center. The 5th Workshop, held in Cambridge, united kingdom, in 1988, dwelt at the results of inhomogeneity of the cardiac muscle on its functionality in overall healthiness and illness. The 6th Workshop highlighted the function of latest modem imaging thoughts, that let us to realize extra perception into neighborhood and international cardiac functionality in cardiac examine and scientific practice.

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Barry: The contractility experiments with Angiontensin II were primarily done in bicarbonate buffer media. The voltage clamp experiments were done primarily in Hepes buffer medium. We have found a positive inotropic effect in both Hepes and bicarbonate buffer medium, but we have not really compared the magnitude of the effects sufficiently to allow any comment about it. Qr. Gania Kessler-Icekson: What is the dose dependency of this effect? 100 nM is a relatively high concentration of Angiontensin II.

1985;34:2525-2530. Harnlyn 1M, Blaustein MP, Bova S, DuCharme DW, Harris DW, Mandel F, Mathews WR Ludens JH. Identification and characterization of ouabain-like compound from human plasma. Proc Natl Acad Sci USA. 1991;88:6259-6263. r- 30 Lichtstein 45. Goto A. Ishiguro T, Yamada K, Ishii M, Yoshioka M, Eguchi C, Shimura M, Sugimoto T. Isolation of a urinary digitalis-like factor indistinguishable from digoxin. Biochem Biophys Res Commun. 1990;173:1093-1101. Lichtstein D, Gati I, Samuelov S, Berson D, Rozenman Y, Landau L, Deutsch J.

Dr. H. Strauss: One would predict minimal antiarrhythmic efficacy for a compound that has similar association and dissociation kinetics to that of 4-AP. The reason for this is that the drug's net effect on repolarization is likely to be maximal at slow heart rates and minimal at fast heart rates. This would predispose the heart toward Tosades de pointes and confer relatively little antiarrhythmic protection during tachycardia when one would like to achieve maximal antiarrhythmic effect. Dr. E. Maroon: Could you comment on the mechanisms of 4-AP blockade of different K+ channels as most of the experiments have been implemented in more than one cell type.

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