By G. M. Hahn (auth.), Dr. Leonore Handl-Zeller (eds.)
This ebook provides all potent and secure strategies in interstitial hyperthermia and provides examples of functions in components of scientific curiosity. Interstitial hyperthermia has been preferentially authorized via oncologists since it could be simply mixed with different kinds of remedy. one of many imperative merits is the threedimensionally constrained warmth deposition to the tumor web site. The contributions during this booklet are written by means of specialists within the fields of biology, physics, and scientific implementation. The technical and medical state-of-the-art in addition to caliber coverage in interstitial hyperthermia is gifted and useful info for the oncologists operating during this box is given.
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Extra info for Interstitial Hyperthermia
Int J Radiat Oll( Biol Phys 5: 1487-1489 Meyn RE, Corry PM, Fletcher SE, Dem riades M (1980) Thermal enhancement DNA damage in mammalian cells treat Local Hyperthermia in Combination with Chemotherapeutic Agents with cis-diamminedichloroplatinum (11). Cancer Res 40: 1136-1139 Morgan JE, Bleehen, NM (1981) Response of EMT6 multicellular tumour spheroids to hyperthermia and cytotoxic drugs. Br J Cancer 43: 384-391 Murray D, Milas L, Meyn RE (1984) DNA damage produced by combined hyperglycemia and hyperthermia in two mouse fibrosarcoma tumors in vivo.
Drugs which are enhaneed at elevated temperatures a. Alkylating agents (probably all) CycIophospamide (Cytoxan) Thio-TEPA [tris (l-aziridinyl)phosphine sulfide] Melphalan (phenylalanine mustard, L-PAM) Nitrosourea [1 ,3-bis(-2-ehloroethyl)N-nitrosourea; BCNU (earmustine), CCNU (domustin), methy-CCNU] Chlorambueil (Mitomyein C - this is an antibiotie, but the mechanism is alkyl at ion) b. Antimetabolites (probably none) e. Antibioties Bleomyein Actinomycin D Adriamyein Daunorubicin Mitoxantrone Quelamyein Mitomyein C d.
150 2 00 250 5-FU 00 •• ; mglkg CY. BLM & 5-FU 22 22 ,. 20 ! ·l··· 11 ,. l::~··· ·J······l· " 12 10 '0 I .. ,.. '0 0 ,. • I 10 20 30 eCHU 00 .. d oDc:"" 0 Orug 00 •• Leve' FS. ~ l'UmM" •, Fig. 4. Response of FSa-1I tumors to combined chemotherapy and hyperthermia (at 41SC). The TG time is plotted as a function of drug dose. RT indicates that animals received drug alone at room temperature. Drugs are CY, cis-DDP, BCNU, BLM and 5FU. Right bottom panel indicates multiple drugs (CY, BLM + 5FU) correlated with the order of the magnitude of activation energies for these agents, including 5FU which showed a minimum activation energy and insignificant sensitization (see Table 1) .