Influence of Tumor Development on the Host by H. E. Kaiser (auth.), Lance A. Liotta (eds.)

By H. E. Kaiser (auth.), Lance A. Liotta (eds.)

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In normal individuals, decreased caloric intake results in a reduction in resting energy expenditure. In one study, half of the cachectic cancer patients demonstrated normal BMR's, while the other half had BMR's 20% greater than the mean value (112). In contrast to many studies demonstrating increased BMR's in malnourished cancer patients, a more recent study conducted by the National Cancer Institute, in which BMR was measured by both direct and indirect calorimetry, failed to find elevations in the BMR of patients with advanced nonsmall cell lung or colorectal cancers, when compared to age-matched patients with nonmalignant disease and disease-free controls (Nixon-1985; unpublished results).

107. 108. 109. 110. 111. 112. 113. Bodel P: Tumors and fever. : Acute tumor lysis syndrome: a review of 37 patients with Burkitt's lymphoma. Am J Med 64:486-491, 1980 Glenner G: Amyloid deposits and amyloidosis: the [:I-fibrilloses. New Engl J Med 302:1283-1292; 1333-1343, 1980 Heber D, Byerly L, Chlebowski R: Metabolic abnormalities in the cancer patient. l):225-229, 1985 Holroyde C, and Reichard G: Carbohydrate metabolism in cancer cachexia. Cancer Treat Rep 65(Suppl. 5):55-59, 1981 Mundy G, and Martin T: The hypercalcemia of malignancy: pathogenesis and management.

Such associated with malignancy influence the micronutrient variations have also been reported in animal studies, almetabolism of the host, is largely unknown. The majority of though studies from different laboratories do not agree. , showed that hepatomas from rats fed played by the micronutrients have been explored most thor- tocopherol-deficient diets, and then supplemented with the oughly at the subcellular level. Of the micronutrients known vitamin, accumulated tocopherol faster than surrounding to be important for animal and human nutrition, the follow- normal liver (91).

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