Humic Substances in Drug Development by KHANNA RAJESH ET.AL

By KHANNA RAJESH ET.AL

There are many traditional humic ingredients which were pointed out and used as a part of conventional drugs all over the world. The utilization has advanced from centuries of information sharing, cautious commentary and functional event received from utilizing those striking bio-products of nature. Shilajit or Mummiyois one such humic substance that has been used for hundreds of years as a part of people drugs and has been ascribed with marvelous rejuvenating and therapeutic homes. study over the past century has confirmed a few those historic claims to be real. contemporary study via the authors has verified impressive drug complexing and bioavailability bettering homes of humic elements derived from Shilajit which may advantageously be used for expanding the solubility, dissolution, permeability and as a result bioavailability of frustrating medicinal drugs of recent method of medication. loads of curiosity has lately been generated among the foreign clinical neighborhood in learning the character and purposes of humic ingredients like Shilajit in smooth drug improvement. the current e-book attempts to collate all this and different extraordinary houses of humic ingredients less than one disguise. the current ebook is a single-source reference paintings to hide the vintage in addition to glossy reviews in this conventional herbo-mineral old treatment. This publication goals to spotlight the traditional claims of Shilajit, how those were demonstrated and reports information regarding its incidence, nature and makes use of in conventional and glossy approach of drugs. It additionally describes the extraction of novel elements, fulvic and humic acids from Shilajit and their use as bioavailability enhancers in glossy medication.

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Therapeutic effect of the drug is caused by the presence of phenol carboxylic acids, amines, vitamins, and microelements in its composition. The preparations stimulate metabolic processes in organism, accelerate regeneration ability, increase the organism resistance to unfavorable factors, and activate immunity. The drug does not possess allergic, teratogenic, and carcinogenic properties. , 2002). The drug is also recommended against radiculites and neuralgias. In gynecology, it is used against chronic inflammatory processes.

4) has reported the presence of a number of trace elements in the water-soluble fractions of different shilajit samples when analyzed by atomic absorption spectroscopy and high-performance thin layer chromatography. 003 52 Humic Substances in Drug Development UV·VIS Spectroscopy UV-vis spectra of various shilajit samples from India were obtained on a Shimadzu, 1601 UVNIS spectrophotometer by dissolving the various shilajit samples in water and recording the spectra in a l-cm quartz cuvette by scanning from 200 to 800 nm (Khanna, 2005).

Since humic substances usually yield uncharacteristic spectra in the UV and visible region, E4/E6 ratio (ratio of the absorbance of the solution at 465 and 665 nm) (Schnitzer, 1972) was determined for the various samples. 3, the UV-vis spectra of the various samples of shilajit did not exhibit any sharp maxima and the absorbance value decreased with increasing wavelength. A lack of maxima can be expected considering the complicated, multi component nature of shilajit with the variety of chromophores of its constituents contributing variable absorptivities.

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