Functional Genomics, Proteomics in Clin. Neuroscis. [Prog. by S. Hemby

By S. Hemby

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Levitt, P. and Mirnics, K. (2002) Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disorders. Neurochem. , 27: 1049–1063. Pounds, S. and Cheng, C. (2004) Improving false discovery rate estimation. Bioinformatics, 20: 1737–1745. A. (2005) Multiple roads to the aging phenotype: insights from the molecular dissection of progerias through DNA microarray analysis. Mech. , 126: 461–465. X. F. (2004) Empirical evaluation of data transformations and ranking statistics for microarray analysis.

A) A TC primer (containing a bacteriophage promoter sequence for sense orientation) and a poly d(T) primer are added to the mRNA population to be amplified (green rippled line). First-strand synthesis (blue line) occurs as an mRNA–cDNA hybrid is formed following reverse transcription and TC of the oligonucleotide primers. After an RNase H digestion step to remove the original mRNA template strand, second-strand synthesis (red line) is performed using Taq polymerase. The resultant double-stranded product is utilized as template for in vitro transcription, yielding high fidelity, linear RNA amplification of sense orientation (green rippled lines).

Shaoli Che, and Ms. Irina Elarova for expert technical assistance. Support comes from the NIA (SDG, AG10668, AG14449, AG17617, and AG09466), NIMH (KM, MH067234, MH45156, 33 and MH070786), and NINDS (SDG, NS43939, and NS48447). We also express our appreciation to the families of the patients studied here who made this research possible. , West, A. and Lahesmaa, R. (2003) Computational strategies for analyzing data in gene expression microarray experiments. J. Bioinform. Comput. , 1: 541–586. , Charles, V.

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