Epithelial Organization and Development by David R. Garrod, Jane E. Collins (auth.), Tom P. Fleming

By David R. Garrod, Jane E. Collins (auth.), Tom P. Fleming (eds.)

Epithelia are one of many most common tissue kinds within the animal state. Chapters from top scientists within the significant overseas examine laboratories use examples from varied structures to demonstrate the shape and serve as of epithelia. a massive subject matter is the best way epithelial cells differentiate to really expert tissue - reversal of this strategy happens whilst cells develop into tumorigenic.

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1988) Lowe et al. (1988) Jansen et al. (1979) Martin (1964) Mazariegos et al. , 1991). The authors speculate that this may be mediated via the cytoskeleton. 3 have been accompanied by careful ultrastructural studies in order to monitor associated alterations in junction structure. In many instances diminution in strand number, dissolution or separation of strands have been shown to accompany permeability increases and vice versa. A study by Madara and Pappenheimer (1987) on hamster intestinal epithelium suggests that such changes in junction structure may be directly regulated by the actin cytoskeleton which associates directly with the cytoplasmic face of the tight junctions in this tissue (Madara, 1987).

1986). , 1986). , 1986). , 1989). , 1988). This may be significant in relation to growth regulation by the growth factors. , 1989). , 1991). The wnt-l protein is secreted, and it is speculated that the effect on gap junctional permeability is mediated via a cell surface receptor-signal transduction mechanism, although these remain to be identified. Rapid changes in junctional permeability in response to the action of modulating agents would seem to require some direct method of opening and closing (gating) the connexon channels.

51-77. A. B. (1974) The splitting of hepatocyte gap junctions and zonulae occludentes with hypertonic disaccharides. J. , 61,575-90.

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