By Cristin O'Keefe Aptowicz
A enthralling biography of the intense and whimsical clinical innovator who revolutionized American surgical procedure and based the country's most famed museum of clinical oddities
Imagine present process an operation with no anesthesia played via a healthcare professional who refuses to sterilize his tools—or even wash his fingers. This was once the area of medication whilst Thomas Dent Mütter all started his trailblazing occupation as a plastic doctor in Philadelphia throughout the center of the 19th century.
Although he died at simply forty-eight, Mütter was once an audacious scientific innovator who pioneered using ether as anesthesia, the sterilization of surgical instruments, and a compassion-based imaginative and prescient for supporting the critically deformed, which clashed spectacularly with the emotions of his time.
Brilliant, outspoken, and overtly good-looking, Mütter was once flamboyant in each point of his existence. He wore red silk fits to accomplish surgical procedure, extra an umlaut to his final identify simply because he may, and gathered an enormous selection of scientific oddities that will later shape the root of Philadelphia's Mütter Museum.
Award-winning author Cristin O'Keefe Aptowicz vividly chronicles how Mütter's efforts helped identify Philadelphia as an international mecca for clinical innovation—despite excessive resistance from his a number of opponents. (Foremost between them: Charles D. Meigs, an influential obstetrician who loathed Mütter's "overly" sleek clinical opinions.) within the narrative spirit of The satan within the White City, Dr. Mütter's Marvels interweaves an eye-opening portrait of nineteenth-century drugs with the riveting biography of a guy as soon as defined because the "P. T. Barnum of the surgical procedure room."
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Additional info for Dr. Mütter's Marvels: A True Tale of Intrigue and Innovation at the Dawn of Modern Medicine
Thoracic duct 5. Esophagus Tumors ‡ Thymoma Germ cell tumor Lymphoma Thyroid adenoma Parathyroid adenoma Lipoma Carcinoma Hemangioma Bronchogenic cysts Pericardial cysts Lymphoma Neurogenic tumors Lymphoma Enteric cysts ‡ Most common in bold Hopkins General Surgery Manual 32 Role of thymoma and Myasthenia Gravis: Resecting thymus in MG, even in absence of thymoma, improves symptoms in 90%, as thymus has been implicated in producing post‐synaptic anti‐Ach‐antibodies Complete remission most likely if: age < 60 and operation performed < 8 months from diagnosis Radiate thymoma after excision only if margins positive and consider platinum‐based chemotherapy.
RIND (Reversible Ischemic Neurologic Deficit): 24 – 48 hour resolution 4. Fixed deficit: stroke Risks of Stroke: 700,000 per year 160,000 deaths/year 1 year post stroke Æ 2/3 of survivors have disability TIA: 15% stroke in first year, then about 6% per year thereafter (40% chance of stroke in 5 years without ASA) Cortical TIA Vertebral TIA Unilateral Dizzy Arm weakness Bilateral “woozy” Decreased vision “Drop attack” (transient loss of motor tone) Asymptomatic: Carotid Stenosis Stenosis > 50%: about 4% per year Stenosis > 80%: 35% risk over 2 years 2% per year risk of stroke for patients > 60 Low resistance arterial systems (such as ICA): total blood flow does not decrease until stenosis > 50%.
Clinical Classification 1. Asymptomatic: bruits (+ bruit Æ 30 – 50% have significant stenosis; + significant stenosis Æ 20 – 50% bruit; Bruit are actually a significant predictor of cardiac disease) 2. TIA: < 24 hour resolution (90% resolve within 2 hours) 3. RIND (Reversible Ischemic Neurologic Deficit): 24 – 48 hour resolution 4. Fixed deficit: stroke Risks of Stroke: 700,000 per year 160,000 deaths/year 1 year post stroke Æ 2/3 of survivors have disability TIA: 15% stroke in first year, then about 6% per year thereafter (40% chance of stroke in 5 years without ASA) Cortical TIA Vertebral TIA Unilateral Dizzy Arm weakness Bilateral “woozy” Decreased vision “Drop attack” (transient loss of motor tone) Asymptomatic: Carotid Stenosis Stenosis > 50%: about 4% per year Stenosis > 80%: 35% risk over 2 years 2% per year risk of stroke for patients > 60 Low resistance arterial systems (such as ICA): total blood flow does not decrease until stenosis > 50%.