Cytoplasmic fate of messenger RNA by F. Amaldi, P. Pierandrei-Amaldi (auth.), Prof.Dr. Philippe

By F. Amaldi, P. Pierandrei-Amaldi (auth.), Prof.Dr. Philippe Jeanteur (eds.)

Among all mobile RNA species of the 3 major kinds, ribosomal RNA, move RNA or messenger RNA, be they from prokaryotic or eukaryotic organisms, the prokaryotic mRNA is exclusive in that it has no precursor and is synthesized within the comparable mature shape because it is translated into proteins. in truth, ribosomes subscribe to the nascent mRNA chain and interact in protein synthesis lengthy prior to its transcription is entire. Provisions are even made for slowing down the ribo­ somes at a few websites to avoid them from catching up with the RNA-polymerase. in fact, this kind of state of affairs is simply attainable within the prokaryotic international the place there is no nuclear mem­ brane bodily secluding the transcription method from the cy­ toplasm the place translation is particular. relatively within the contrary severe, the eukaryotic pre-messenger RNA has to endure many and occasionally drastic steps of maturation (capping, polyadenylation, splicing, version) sooner than the choice is made to export it to the cytoplasm. that's the place it enters the scope of this booklet. as soon as within the cytoplasm, many thoughts are nonetheless open to it: its front into polysomes could be behind schedule (as it truly is in unfertilized eggs) or only prohibited (ferritin mRNA in iron-starved cells), directed to precise destinations in the cytoplasm or be roughly quickly degraded. in the course of gametogenesis and early improvement, translational keep watch over is without doubt one of the most important point of gene expression.

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Salmo gairdneri and Xenopus laevis) were compared. These sequences can be found in Genbank with the following mnemonics respectively: SEICMYC, CRACMYC, CATMYCCA3, CHPCMYC, ASRCMYC, HSMYCC, ZEFZCMYC, CHKMYC, MUSCMYC2, SMOMYC and XELMYC 3' Untranslated Regions of c-myc and c-fos mRNAs 37 Thus, ARE appear to be involved in multiple functions and this is reflected at the level of their structure. Previous results have suggested that c-fos ARE can be divided into two structurally and functionally distinct domains (Chen et al.

As stated above, it is known that RNase L is inhibited by some viruses, and in particular by EMCV. RLI mRNA level is increased during EMCV infection. The transfection of HeLa cells by RLI antisense cDNA inhibits the induction of RLI mRNA by EMCV and reverses the inhibition of RNase L (Martin and et al. 1994). RLI must, therefore, be the inhibitor of the 2-5AjRNase L RNA Degradation System in Mammals inactive O/2-SA 29 complex hydrolysed ~-5A 5' 3' 3' L~UPNP Ps ' active complex inactivable complex Fig.

S for p40 (Mory et al. 1989). The human p69 was cloned in 1992 (Marie and Hovanessian 1992). The first 683 amino acids of this p69 synthetase present some homology (50%) with the first 346 amino acids of p40 and p46. S at a concentration of 100 Jlg/ml of dsRNA. p69 exists as a dimer. RNA Degradation System in Mammals 23 I INTERFERON I /~ oligo(A)-synthetase(s) inactive PKR inactive I dSRNA AlP I ---------AlP - 2 - S A j activation elF2 IxB-NF-xB - activation eIF2-P IxB-P, N F-xB RNase L ! degradation of mRNA rRNA, viral RNA inhibition of translation induction of transcription of some mRNAs Fig.

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