Current Concepts of Intestinal Failure by Risto J. Rintala, Mikko Pakarinen, Tomas Wester

By Risto J. Rintala, Mikko Pakarinen, Tomas Wester

This e-book presents readers with a succinct yet complete assessment of present techniques when it comes to intestinal failure, together with its remedy, with a selected specialize in contemporary developments. the outlet chapters handle simple points of intestinal failure, together with etiology, scientific pathophysiology, body structure of intestinal model, and intestinal microbiota. The issues of intestinal failure, corresponding to bacterial overgrowth and intestinal failure-associated liver disorder, are then mentioned. a sequence of chapters in particular deal with very important options within the dietary, pharmacological, and surgical procedure of intestinal failure in addition to the idea that of intestinal rehabilitation. eventually, major rising advancements are thought of: regenerative drugs and distraction enterogenesis. The authors are the world over well-known specialists from Europe and North the USA who're preferably positioned to explain present wisdom and growth within the field.

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59. Wilmore DW, Lacey JM, Soultanakis RP, Bosch RL, Byrne TA. Factors predicting a successful outcome after pharmacologic bowel compensation. Ann Surg. 1997;226:288–92. 60. Matarese LE, Seidner DL, Steiger E. Growth hormone, glutamine, and modified diet for intestinal adaptation. J Am Diet Assoc. 2004;104:1265–72. 61. Drucker DJ. Gut adaptation and the glucagon-like peptides. Gut. 2002;50:428–35. 62. Litvak DA, Hellmich MR, Evers BM, Banker NA, Townsend Jr CM. Glucagon-like peptide 2 is a potent growth factor for small intestine and colon.

76. 77. 78. 79. 80. 81. 82. nal re-growth following massive small bowel resection in rat. Pediatr Surg Int. 2006;22:9–15. Sukhotnik I, Khateeb K, Krausz MM, Sabo E, Siplovich L, Coran AG, Shiloni E. Sandostatin impairs postresection intestinal adaptation in a rat model of short bowel syndrome. Dig Dis Sci. 2002;47:2095–102. Sukhotnik I, Shiloni E, Mogilner J, Lurie M, Hirsh M, Coran AG, Krausz MM. Effect of sex and sex hormones on structural intestinal adaptation after massive small bowel resection in rats.

Adaptation and Peptide Growth Factors Over the past decades, several proteins produced by different cells and tissues, designated peptide growth factors, have been reported to play an important role in stimulating enterocyte turnover. Our understanding of the structure and function of the peptide growth factors has advanced rapidly in recent years. Peptide growth factors appear to mediate many of the processes required for normal intestinal growth and differentiation. Every growth factor modulates growth through autocrine, juxtacrine, or paracrine mechanisms and usually acts as a mitogen through the stimulation of specific cell surface receptors.

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