By B. M. Gorman (auth.), Polly Roy MSc, Ph.D., Barry M. Gorman MSc, Ph.D. (eds.)
Bluetongue viruses (BTV) reason ailments that experience severe fiscal outcomes in ruminants (sheep, farm animals) in lots of elements of the realm. The prevalence of bluetongue sickness impacts the foreign circulate of animals and germ plasm. even though the etiological agent of the disorder used to be remoted in 1900 and initial biochemical characterizations have been pub lished as early as in 1969, many of the present knowing of the molecular biology, biochemistry, and genetics of BTV has developed only in the near past. prompted by means of the fashionable innovations of molecular biology, genetics, and immunology, BTV learn has skilled a knowledge explosion some time past 10 years. although, a lot of this data is scattered all through an intensive literature. it's hence a suitable time to meld this jointly right into a reference ebook. This e-book comprises compre hensive info on BTV examine supplied in articles contributed through researchers from world wide. It covers what's identified concerning the molecular constitution of the virus and the present realizing of its biology, evolution, and relationships with its invertebrate and vertebrate hosts (infection, immunity, and pathogenicity).
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Additional info for Bluetongue Viruses
The two major nonstructural proteins, NS1 (P5A) and NS2 (P6A), were first identified by HUISMANS (1979). A third minor nonstructural protein, NS3, was first detected by GORMAN et al. (1981) in BTV-infected cells. The synthesis of nonstructural proteins NS1 and NS2 in BTV-infected cells coincides with that of the structural proteins (HUISMANS 1979). Protein NSI is synthesized in large amounts, comprising about 25% of the virus-specified proteins in the infected cells. However, very little NSI is detected in the soluble fraction of infected cells because it is very rapidly converted to high molecular weight tubular structures with a sedimentation coefficient of about 300S-500S (HUISMANS 1979; HUISMANS and ELS 1979).
57 Segment 3, VP3. . . . . . . . . . . . . . . . . . . . .. 62 Segment 4, VP4 . . . . . . . . . . . . . . . . . . . . 66 Segment 5, VP5. . . . . . . . . . . . . . . . . . . . .. 66 Segment 6, NSI. . . . . . . . . . . . . . . . . . . . 68 Segment 7, VP7 . . . . . . . . . . . . . . . . . . . . 68 Segment 8, NS2. . . . . . . . . . .
In: Fraenkel-Conrat H, Wagner RR (eds) Comprehensive virology vol 14. Plenum, New York pp 285-345 Wade-Evans AM, Pan ZQ, Mertens PPC (1988) In vitro expression analysis of a cDNA clone of genome segment 5 from bluetongue virus, serotype 1 from South Africa. Virus Res 11: 227-240 Waldvogel AS, Stott JL, Squire KRE, Osburn BI (1986) Strain-dependent virulence characteristics of bluetongue virus serotype 11. J Gen Virol 67: 765-769 Whistler T, Newman JFE (1986) Peptide mapping of the group-specific antigens from the Australian bluetongue virus (BTV-20) and serotypes from Southern Africa and North America.